بررسی ارتباط سطح سرمی هوموسیستئین با مرگ و میر و عوارض انفارکتوس میوکارد

Abstract Background and purpose: There is strong correlation between cardiovascular diseases and risk factors such as hypertension, diabetes mellitus, serum cholesterol level. However, only 50% of coronary arteries diseases (CADs) are associated with such factors. Different studies investigating the correlation between homocystein and CADs found different or even paradoxical results. This study aimed at investigating the association between plasma homocystein levels with mortality and complications of Myocardial Infarction. Materials and methods: A cross-sectional study was carried out on patients admitted to hospital complaining from chest pain during 24 hr who had no history of previous MI and with the diagnosis of STEMI. The patients were divided into two groups of normal and increased homocystein level. They were followed during hospitalization to determine complications of STEMI and mortality rate. Results: From the total of 230 patients, normal homocystein levels was observed in 150 patients (65.2%) and 80 patients (34.8%) had increased homocystein level. Death occurred in two patients with normal homocystein level, and in four patients with increased level of homocystein. Electrical complications were seen in 40 cases among patients with normal homocystein level and in 19 cases among the other group. Mechanical complications (including 2 VSD and 1 tamponade) were detected in patients with increased homocystein level, while these complications were not fond in the other group. Also, no mitral regurgitation was seen due to rupture in papillary or chordae muscles. Conclusion: This study found that there was not a significant difference between two groups of normal and increased homocystein level regarding mortality rate and electrical complications. However, among mechanical complications, VSD and tamponade were significantly greater in the group with increased level of homocystein.